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KMID : 0619020000090020196
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Hae Hwa Medicine
2000 Volume.9 No. 2 p.196 ~ p.209
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A Study on the Anti-metastasis and Immune activity of Cordyceps sinensis extract.
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Abstract
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This experimental study was carried out to evaluate the effects of Cordiceps sinensis on the antimetastasis and immune activity. In order to investigate the effect of Cordiceps sinensis, the followings were performed; Cytotoxicity, inhibition of MMP-2 & MMP-9 gene expression, fraction of CD4+, CD8+, CD19+ in splenic cell, the moprphological change of splenic cells, gene expression of IL-12(p35), IL-12(p40), IFN-?? and splenic cell proliferation by CS-E.
The results were obtained as follows.
1. CS-E did not present cytotoxic effect on L+14, B16-F10 melanoma cells and HMCB.
2. CS-E inhibited MMP-2 and MMP-9 gene expression more effectively compared with control group.
3. CS-E inhibited invasion of B16-F10 melanoma cells more effectively compared with control group.
4. CS-E helped CD4+, CD8+, CD19+ expression more effectively compared with control group.
5. CS-E activated phagocytic cells in spleen more effectively compared with control group.
6. CS-E helped IL-12(p35), IL-12(p40), IFN-?? gene expression in splenic cell more effectively compared with control group.
7. CS-E activated splenic cell proliferation more effectively compared with control group.
From above findings, it is suggested that CS-E is able to inhibit metastasis of cancer and activate immune response system.
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KEYWORD
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